Epiduo Acne Gel is safe during pregnancy? (First quarter)?
Hi, I have nine weeks of pregnancy and stopped using my Epiduo gel because I wonder if it could harm the baby in any way. Well, I'm bad luck and doctors has been completed, but none of you know if it is safe to use? Thanks in advance:)
Pregnancy Category C. Pregnancy There are no well-controlled studies in pregnant women treated with Epiduo Gel. Animal reproduction studies was performed with the gel or a combination of benzoyl peroxide. Moreover, these studies are not always predictive of human response, and therefore, the gel should be used during Epiduo pregnancy only if the benefit justifies the potential risk to the fetus. There were no teratogenic effects have been observed in rats treated with oral doses of 0.15 to adapalene 5.0 mg / kg / day, up to 25 times (mg / m² / day), the maximum recommended human dose (MRHD) of 2 grams of Epiduo Gel. However, changes were observed teratogenic in rats and rabbits treated with oral doses of adapalene 25 mg / kg / day or 123 to 246 times MRHD, respectively. Findings included cleft palate, microphthalmia, encephalocele and skeletal abnormalities in rats, and an umbilical hernia, exophthalmos and kidney and skeletal abnormalities in rabbits. Teratology studies Skin rats and rabbits at doses of adapalene 0.6 to 6.0 mg / kg / day [25-59 times (mg / m²) the MRHD] showed no fetal toxicity and only a minimal increase of ribs supernumerary in the two species and delayed ossification in rabbits.